Myeloproliferative neoplasms are a group of rare blood cancers in which the bone marrow becomes overactive, causing the cells to develop and function abnormally. MPNs originate in the bone marrow: the soft tissue in the middle of your bones where blood cells are produced. Myeloproliferative neoplasms can strike anyone at any age. The three main MPNs are myelofibrosis, polycythemia vera, and essential thrombocythemia. There are several treatment options, and one new drug specifically for myelofibrosis was approved in 2012. Clinical trials are underway for other drugs for all three MPNs.
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