May 27, 2025
Author(s): Dr. Tiziano Barbui
Fact checked by: Spencer Feldman
Excess blood cell production in two myeloproliferative neoplasms (MPNs) — essential thrombocythemia, or ET, and polycythemia vera, also known as PV — can impair circulation, according to Dr. Tiziano Barbui.
Barbui is a professor of hematology and founder of the department of hematology at Bergamo Hospital. He is currently the scientific director of clinical research foundation at Papa Giovanni XXIII Hospital, Bergamo, Italy.
In a video interview with CURE, Barbui explained that both diseases begin in the bone marrow and are marked by abnormal increases in blood cell counts. In polycythemia vera, red blood cells are overproduced, increasing blood viscosity and making it harder for blood to flow through small vessels. In essential thrombocythemia, the problem lies with excess platelet production.
Barbui emphasized that treatment is essential not only to relieve symptoms but also to prevent more serious complications linked to impaired blood circulation in both MPNs.