Lucia Masarova, MD, an assistant professor in the Department of Leukemia in the Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center, discusses the efficacy of CPI-0610 in the phase 2 MANIFEST (NCT02158858) trial in patients with myelofibrosis. Masarova says that CPI-0610, a bromodomain, and extra-terminal (BET) inhibitor holds promise in patients […]
Combinations of JAK inhibitors and novel agents, such as epigenetic regulators, could help prolong survival in patients with myeloproliferative neoplasms (MPNs), providing patients with more than a reduction in spleen size and symptomatic relief, explained Shella Saint Fleur-Lominy, MD, PhD, who added that for patients who have already progressed on ruxolitinib (Jakafi), fedratinib (Inrebic), momelotinib, […]
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Myeloproliferative neoplasms are a group of rare blood cancers in which the bone marrow becomes overactive, causing the cells to develop and function abnormally. MPNs originate in the bone marrow: the soft tissue in the middle of your bones where blood cells are produced. Myeloproliferative neoplasms can strike anyone at any age. The three main […]
Myelofibrosis occurs in about 1.5 out of every 100,000 people in the United States annually. Men, women and children can all be affected and more people are being diagnosed at an earlier age. Myelofibrosis is a type of chronic blood cancer that can occur on its own or as the result of another bone marrow […]
Polycythemia Vera (PV) is one of the myeloproliferative disorders in which the bone marrow makes too many red blood cells. It may also result in the production of too many other types of blood cells, such as white blood cells and platelets. Red blood cells carry oxygen to the body. White blood cells fight infection. […]