Chicago, IL, November 1, 2021 (Newswire.com) – In realworld usage and in clinical trials, interferon (IFN) in a variety of forms has shown high rates of hematologic and molecular responses in many patients with rare blood cancers known as myeloproliferative neoplasms (MPNs). Other patients have no significant response, and some develop drug resistance to recombinant interferon over time.
A report summarizing a three-year Interferon Initiative, released today by the MPN Research Foundation, sheds light on the reasons for these varying responses, and may have impactful applications not only for MPNs − including polycythemia vera, essential thrombocythemia and myelofibrosis − but also for other blood cancers and solid tumors.
“The initiative brought together multi-institutional investigations by key researchers from across the US, Europe and Australia to uncover a deeper understanding of the mechanisms by which interferon works for patients with an MPN,” said Barbara Van Husen, MPNRF board chair.