Arthritis Medicine May Move on to PV Treatment Scene

Can a drug used to treat arthritis also be a way to treat polycythemia vera (PV), and save patients with the blood cancer money?

Researchers at the University of Sheffield in England believe that the chemotherapy agent and immune system suppressant, methotrexate (MTX), would benefit tens of thousands of people affected by the disease.

The reason an arthritis treatment may work to treat the rare cancer type is because they both have connections to the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway. In patients with arthritis, it sparks up inflammation and an autoimmune response, and for PV, mutations in the pathway account for the majority of diagnoses.

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