A chart review of patients with myeloproliferative neoplasms (MPN) who developed unexplained leukocytosis or thrombocytosis demonstrated that these patients should be evaluated for chronic myelogenous leukemia (CML), according to a case series described in a published abstract from the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.1
Myeloproliferative neoplasms (MPN) are classified by the presence of the Philadelphia chromosome (Ph). Ph-negative MPN typically possesses driver mutations of JAK-2, MPL, and CALR genes. CALR is involved with apoptosis and cell proliferation, and MPL leads to thrombopoietin receptor stimulation. JAK-2 mutations render hematopoietic stem cells more sensitive to growth.