Pacritinib More Effective at Spleen Volume Reduction Than Best Available Therapy in MF

Treatment with the multityrosine kinase inhibitor pacritinib resulted in a significant reduction in spleen volume compared with best available therapy, including ruxolitinib, in patients with myelofibrosis and thrombocytopenia, according to a study presented at the American Society of Hematology (ASH) 58th Annual Meeting & Exposition.

For the phase 3 PERSIST-2 study (ClinicalTrials.gov identifier: NCT02055781), investigators enrolled 311 patients with primary, postpolycythemia, or postessential thrombocythemia myelofibrosis and platelet counts no greater than 100,000/µL. Participants were randomly assigned to receive pacritinib 200 mg orally twice daily, pacritinib 400 mg orally once daily, or best available therapy, including ruxolitinib.

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